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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TBCC All Species: 11.82
Human Site: S164 Identified Species: 20
UniProt: Q15814 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15814 NP_003183.1 346 39220 S164 G I P P A V E S I Q D S P L P
Chimpanzee Pan troglodytes XP_518477 346 39236 S164 G I P P A V E S I Q D S P L P
Rhesus Macaque Macaca mulatta XP_001088723 346 39322 S164 G I P P A V E S L R D S P L P
Dog Lupus familis XP_538923 388 42549 I206 G P A A A E G I L A F P P P L
Cat Felis silvestris
Mouse Mus musculus Q8VCN9 341 38106 A159 D A A P V T S A A P S P P V T
Rat Rattus norvegicus NP_001101670 340 38058 S158 V D A A P V T S A A P S P P L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508991 335 37102 A153 A T P G P V P A A A A P A P A
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922489 350 39443 T159 P T P I Q Q Q T A D K P A P G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_722959 355 40503 K149 K P K V P P N K D I V D A K L
Honey Bee Apis mellifera XP_001120828 342 39209 I160 D L K I S E G I V N G S A K Q
Nematode Worm Caenorhab. elegans Q27249 256 29613 S83 D R L K T A T S K L E Q A T K
Sea Urchin Strong. purpuratus XP_783718 353 39965 K171 N K Q Q Q A Q K I G L D V V D
Poplar Tree Populus trichocarpa XP_002307082 324 36492 N142 K P N P G N S N T N P I P P N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_195702 345 38291 P159 K K P E S K L P E I Q K P D V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 95.3 72.9 N.A. 76 74.5 N.A. 61.5 N.A. N.A. 43.7 N.A. 33.5 38.7 21.1 39.6
Protein Similarity: 100 99.1 97.6 78.3 N.A. 84.3 83.5 N.A. 74.5 N.A. N.A. 64 N.A. 57.7 58 40.1 62.6
P-Site Identity: 100 100 86.6 20 N.A. 13.3 26.6 N.A. 13.3 N.A. N.A. 6.6 N.A. 0 6.6 6.6 6.6
P-Site Similarity: 100 100 100 26.6 N.A. 26.6 26.6 N.A. 20 N.A. N.A. 20 N.A. 0 26.6 13.3 20
Percent
Protein Identity: 29.7 N.A. N.A. 32.3 N.A. N.A.
Protein Similarity: 48.2 N.A. N.A. 51.7 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 22 15 29 15 0 15 29 22 8 0 36 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 22 8 0 0 0 0 0 0 8 8 22 15 0 8 8 % D
% Glu: 0 0 0 8 0 15 22 0 8 0 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 29 0 0 8 8 0 15 0 0 8 8 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 22 0 15 0 0 0 15 22 15 0 8 0 0 0 % I
% Lys: 22 15 15 8 0 8 0 15 8 0 8 8 0 15 8 % K
% Leu: 0 8 8 0 0 0 8 0 15 8 8 0 0 22 22 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 8 0 0 8 8 8 0 15 0 0 0 0 8 % N
% Pro: 8 22 43 36 22 8 8 8 0 8 15 29 58 36 22 % P
% Gln: 0 0 8 8 15 8 15 0 0 15 8 8 0 0 8 % Q
% Arg: 0 8 0 0 0 0 0 0 0 8 0 0 0 0 0 % R
% Ser: 0 0 0 0 15 0 15 36 0 0 8 36 0 0 0 % S
% Thr: 0 15 0 0 8 8 15 8 8 0 0 0 0 8 8 % T
% Val: 8 0 0 8 8 36 0 0 8 0 8 0 8 15 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _